Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. matrix tablets by using Eudragit RSPO and natural gums like guar copal as rate The use of synthetic Eudragit RSPO and gum copal were unable to retard the. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.
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Eudragig sample was measured in triplicate. It was applied to determine the significance and the magnitude of the effects of the main variable and their interactions by applying probability value value. It is also known as solvent displacement or interfacial deposition method and was developed about 40 years ago [ 18 ].
Matrix systems are widely used in oral controlled drug delivery because of their flexibility, cost effectiveness, low influence of the physiological variables on its release behavior and broad regulatory acceptance [ 67 ].
Hydrophilic drugs tend to rapidly equilibrate from the organic to the outer aqueous phase leaving very little drug in the precipitating nanoparticles [ 26 ].
This means that the drug payload can be transported by diffusion. Diffusion coupled with erosion might be the mechanism for the drug release from hydrophilic and hydrophobic polymer based matrix rzpo which can be expected to reduce the frequency of administration and decrease the dose-dependent side effects associated with repeated administration of conventional metformin HCl Tablets.
Hausner’s values of the prepared granules ranged from 1. Granulation was done manually with a solution of isopropyl alcohol. As shown in Figure 4 a increasing an amount of polymer resulted in an increase in PDI.
Journal of Nanomaterials
Modification of the traditional method with the use of surfactants improves the EE. In this project we used a modified nanoprecipitation method to encapsulate tenofovir.
D response surface plots showing the effect of a ratio of a polymer to a drug and concentration of a surfactant at constant sonication time and b ratio of a polymer to a drug rs;o sonication time at constant concentration of a surfactant. This can further be seen from 3D surface plots in Figure 3.
A batch of 30 eudrsgit was prepared with each formula. The reduced model for PDI is presented in where and are ratio of a polymer to a drug and concentration of a surfactant, respectively. It was also found that the interaction between ratio of a polymer and sonication time and concentration of surfactant and sonication time significantly influence zeta potential.
The results are expressed as mean standard deviation SD. The overall objective of this study was to develop an oral sustained release metformin hydrochloride tablet by using hydrophilic Eudragit RSPO alone or its combination with hydrophobic natural polymers Gum copal and gum damar as rate controlling factor.
Hence, in the present work, an attempt has been made to formulate the extendedrelease matrix tablets of metformin HCl using hydrophilic polymer Eudragit RSPO alone or in combination with hydrophobic natural polymer, GC and GD to evaluate the in vitro release characteristics and to predict the release behavior. Drops of nanoparticles dispersion were applied on the stub and dried overnight. Mumbai, Indiaand gum copal and gum damar were received as a gift sample from Imex Inc. Moreover, coefficient of determination indicates the proportion of variation in the data that is explained by the model.
An obstacle to more successful eudrwgit of metformin therapy is the rapo incidence of concomitant gastrointestinal symptoms, such as abdominal discomfort, nausea, and diarrhea that especially occurs during the initial period of treatment. Figure 5 in vitro cumulative release of metformin. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled or Fickian transport to eduragit type or non-Fickian transport.
El Baradi, and M. Analysis of variation ANOVA helps to identify the significant independent factors that affect the responses [ 22 ] and the fitness of the model. The reduced mathematical models for mean particle size, EE, average zeta potential, and PDI are presented by 4 to 7respectively. Poly ethyl acrylate-co-methyl methacrylate-co-trimethylammonioethyl methacrylate chloride 1: Mathematical models were developed to understand the nature of the true relationship between the input variables and the output variables of the system [ 32 ].
Time-controlled Drug release
Further, such dense matrix, specifically when it is hydrophobic in nature, may be expected to eudrsgit less penetration of the dissolution medium in the tablets. Three-level, three-factor BBD was used to study the effect of variables in the preparation steps of nanoparticles. The optimized formulation was characterized for in vitro drug release and structural characterization.
Figure 2 in vitro cumulative release of metformin.
Figure 2 provides the 3D response surface plots showing the change of particles size corresponding to the change of independent variables. Side effects, short half lives, low bioavailability and the need for the administration two to three times a day when larger doses are required can decrease patient compliance.
There is minimal drug loss during transit through the gastrointestinal tract while the particles evade degradation in the acidic environment of the stomach. An angle of repose of less than 30 degrees indicates good flow properties. Figure 3 in vitro cumulative release of metformin. Metformin hydrochloride is an orally administered biguanide, which is widely used in the management of type-II diabetes, a common disease that combines defects of both insulin secretion and insulin action [ 1 ].
Login to see your most recently viewed materials here. The completed design consisted of 15 experimental runs, which were done in triplicate. All other ingredients used throughout the study were of analytical grade and were used as received.
Eudragit RSPO | Gum Copal | Gum Damar | Matrix Tablets | Release Kinetics
The prepared matrix tablets were evaluated for hardness, weight variation, thickness, friability euragit drug content [ 19 ]. It has also been used in the preparations of time-controlled drug delivery formulations [ 12 ].
View at Google Scholar L. The objective of present uedragit was to develop an optimized polymeric nanoparticle system for the antiretroviral drug tenofovir.
It is also an important component of the fixed dose antiretroviral combinations Truvada, Atripla, and Complera [ 3 ].