Glucose transporters (GLUT and SGLT): expanded families of Glucose transporter proteins: Diabetes mellitus: Adipose tissue: Muscle: Sugar transport. Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans. Sodium-dependent glucose cotransporters are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the.

Author: Doktilar Daijora
Country: Singapore
Language: English (Spanish)
Genre: Marketing
Published (Last): 4 February 2017
Pages: 109
PDF File Size: 15.50 Mb
ePub File Size: 8.97 Mb
ISBN: 481-3-20323-482-7
Downloads: 54017
Price: Free* [*Free Regsitration Required]
Uploader: Shabei

ATP3 Class I, type 8: A Negatively charged oxygen then transfers its electrons reforming a carbonyl and breaking its bond with glucose. Vesicular glutamate transporter 1 SLC32A1. Chromosome 4 mouse [2].

The GLUT4 glucose transporter.

Proceedings of a Symposium held in Prague, August 22—27, Orphanet Journal of Rare Diseases. From Wikipedia, the free encyclopedia. GLUT1 behaves as a Michaelis-Menten enzyme and contains 12 membrane-spanning alpha heliceseach containing 20 amino acid residues. GLUT 1 is highly conserved. This hypothesis was rapidly tested, refined, and extended [to] encompass the active transport of a diverse range gluoksa molecules and ions into virtually glumosa cell type.

Genes on human chromosome 22 Genes on human chromosome 16 Solute carrier family. This article incorporates text from this source, which is in the public domain.

Glucose 6-phosphatase – Wikipedia

Half a century later this idea has turned into one of the most studied of all transporter proteins SGLT1the sodium—glucose cotransporter. The negatively charged glucose-bound oxygen is then protonated by His forming a free glucose. The SGLT proteins use the energy from this downhill sodium ion gradient created by the ATPase pump to transport glucose across the apical membrane traneporter, against an uphill glucose gradient.


The enzyme plays an important role during periods of fasting and when glucose levels are low. Expression levels of GLUT1 in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. The Journal of Biological Chemistry. Molecular and Cellular Biology portal. Mild mental retardation may also occur.

Lys, Arg, Arg, His, and His Energy-yielding metabolism in erythrocytes depends on a constant supply of glucose from the blood plasmawhere the glucose concentration is maintained at about 5mM. SGLT2 inhibitors, also called gliflozins[4] are used in the treatment of type 2 diabetes.

This page was last edited on 2 Novemberat This article incorporates text from the United States National Library of Medicinewhich is in the public domain. GLUT1 is responsible for the low level of basal glucose uptake required to sustain respiration in all cells. The New England Journal of Medicine. Protein pages needing a picture. Most patients show some degree of cognitive impairment. Glucose enters the erythrocyte by facilitated diffusion via a specific glucose transporter, at a rate about 50, times greater than uncatalyzed transmembrane diffusion.

Glucose 6-phosphatase

However, sequence alignment has shown tansporter glucosephosphatase is structurally similar to the active site of the vanadium-containing chloroperoxidase found in Curvularia inaequalis. Disruption of the glucose to G6P ratio due to significant decrease intracellular glucose levels cause significant disruption of glycolysis and HMS.


Another mutation, ARGCYS, has been shown to cause Dystonia 9 DYT9an autosomal dominant neurologic disorder characterized by childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia. Membrane proteinscarrier proteins: Retrieved from ” https: By group SLC1—10 1: By group SLC1—10 1: Journal of Child Neurology. Retrieved from ” https: The hydrolysis of glucosephosphate begins with a nucleophilic attack on the sugar-bound phosphate by His resulting in the formation of a phosphohistidine bond and the degradation of a carbonyl.

Glucosephosphatase is a complex of multiple component proteins, including transporters for G6P, glucose, and phosphate.

Vanadium compounds such as vanadyl sulfate have been shown to inhibit the enzyme, and thus increase the insulin sensitivity in vivo in diabetics, as assessed by the hyperinsulinemic clamp techniquewhich may have potential therapeutic implications [19] [20]. Mitochondria portal Gene Wiki portal. The glucose transporter of erythrocytes called GLUT1 to distinguish it from related glucose transporters in other tissues is a type III integral protein with 12 hydrophobic segments, each of which is believed to form a membrane-spanning helix.

This page was last edited on 29 Juneat Other variable features may include seizures, migraine headaches, and ataxia.

In some EIG12 patients seizures may remit with age.